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\u7231\u7684\u611f\u89c9\u7684\u4e09\u79cd\u8c03\u8282\u7b56\u7565<\/p>\n\n\n\n
\u8d70\u51fa\u5931\u604b\u6709\u5f88\u591a\u7b56\u7565\uff0c\u800c\u672c\u6587\u805a\u7126\u4e8e\u7231\u7684\u8c03\u8282\u8fd9\u4e00\u65b9\u9762\u3002\u8bb8\u591a\u5b66\u8005\u8ba4\u4e3a\u7231\u662f\u4e00\u79cd\u60c5\u7eea\uff0c\u6240\u4ee5\u4e00\u822c\u7684\u60c5\u7eea\u8c03\u8282\u7b56\u7565\uff08\u884c\u4e3a\u7684\u6216\u8ba4\u77e5\u7684\uff09\u4e5f\u8bb8\u53ef\u7528\u4e8e\u7231\u7684\u8c03\u8282\u3002<\/p>\n\n\n\n
\u6211\u4eec\u5df2\u7ecf\u77e5\u9053\uff0c\u5bf9\u524d\u4efb\u7684\u7231\u7684\u611f\u89c9\u4e0e\u60b2\u4f24\u5448\u6b63\u76f8\u5173\u7684\u5173\u7cfb\uff0c\u4e0e\u81ea\u6211\u6982\u5ff5\u7684\u6062\u590d\u5448\u8d1f\u76f8\u5173\u7684\u5173\u7cfb\u3002\uff08Sbarra&Ferrer,2006,Mason et al.,2012\uff09\u8fd9\u610f\u5473\u7740\uff0c\u5982\u679c\u4e00\u4e2a\u4eba\u5728\u5931\u604b\u540e\u4f9d\u7136\u5f88\u7231\u81ea\u5df1\u7684\u524d\u4efb\uff0c\u90a3\u4e48\u4ed6\u6216\u5979\u5f88\u6709\u53ef\u80fd\u4f53\u9a8c\u5230\u66f4\u9ad8\u7a0b\u5ea6\u7684\u60b2\u4f24\uff0c\u800c\u6062\u590d\u7684\u8fdb\u5c55\u4e5f\u4f1a\u66f4\u7f13\u6162\u3002\u8fd9\u6837\u6765\u770b\uff0c\u901a\u8fc7\u51cf\u8f7b\u7231\u7684\u611f\u89c9\uff0c\u6709\u53ef\u80fd\u8ba9\u5931\u604b\u8005\u66f4\u5feb\u5730\u8d70\u51fa\u9634\u5f71\u3002<\/p>\n\n\n\n
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\u5bf9\u524d\u4f34\u4fa3\u8fdb\u884c\u8d1f\u9762\u8bc4\u4ef7\u3002\u8fd9\u6307\u7684\u662f\u63d0\u9192\u4f60\u81ea\u5df1\uff0c\u4f60\u7684\u524d\u4f34\u4fa3\u6709\u4e00\u4e9b\u6d88\u6781\u54c1\u8d28\uff0c\u6bd4\u5982\u4ed6\u6216\u5979\u559c\u6b22\u8ddf\u522b\u4eba\u8c03\u60c5\uff0c\u5f88\u559c\u6b22\u53d1\u813e\u6c14\uff0c\u4e0d\u5c0a\u91cd\u4f60\uff0c\u6709\u70df\u763e\uff0c\u7b49\u7b49\u3002<\/p>\n\n\n\n
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\u8f6c\u79fb\u6ce8\u610f\u529b\u3002\u8fd9\u6307\u7684\u662f\u5f53\u4f60\u4e3a\u5931\u604b\u611f\u5230\u5fc3\u788e\u7684\u65f6\u5019\u5c31\u53bb\u505a\u70b9\u5176\u4ed6\u8ba9\u81ea\u5df1\u9ad8\u5174\u7684\u4e8b\u60c5\uff0c\u6bd4\u5982\u73a9\u6e38\u620f\u6216\u770b\u7535\u5f71\u3002<\/p>\n\n\n\n
\u4e09\u79cd\u7b56\u7565\u7684\u6bd4\u8f83<\/p>\n\n\n\n
\u5bc6\u82cf\u91cc\u5927\u5b66\u5723\u8def\u6613\u65af\u5206\u6821\u7684Langeslag\u548cSanchez\u901a\u8fc7\u5b9e\u9a8c\u5bf9\u8fd9\u4e09\u79cd\u7b56\u7565\u7684\u6709\u6548\u6027\u8fdb\u884c\u4e86\u6bd4\u8f83\u3002\uff08Langeslag&Sanchez,2018\uff09\u7b80\u5355\u5730\u8bf4\uff0c\u5b9e\u9a8c\u8fc7\u7a0b\u662f\u8fd9\u6837\uff1a\u4ed6\u4eec\u628a\u5931\u604b\u8005\u5206\u6210\u4e09\u7ec4\uff0c\u4e09\u7ec4\u88ab\u8bd5\u5148\u5206\u522b\u8fdb\u884c\u4e0a\u8ff0\u8c03\u8282\u7b56\u7565\uff0c\u7136\u540e\u88ab\u52a8\u5730\u89c2\u770b\u81ea\u5df1\u7684\u524d\u4efb\u7684\u7167\u7247\uff0c\u5728\u6b64\u8fc7\u7a0b\u4e2d\uff0c\u4ed6\u4eec\u7684\u8111\u7535\u56fe\u88ab\u8bb0\u5f55\u4e0b\u6765\u3002\u7b2c\u4e00\u7ec4\u88ab\u8bd5\u4f1a\u88ab\u8be2\u95ee\u5173\u4e8e\u81ea\u5df1\u524d\u4efb\u7684\u6d88\u6781\u65b9\u9762\u7684\u95ee\u9898\uff08\u6bd4\u5982\u201c\u4f60\u7684\u524d\u4efb\u6709\u4ec0\u4e48\u8ba9\u4f60\u607c\u6012\u7684\u4e60\u60ef\uff1f\u201d\uff09\u3002\u7b2c\u4e8c\u7ec4\u88ab\u8bd5\u4f1a\u88ab\u5f15\u5bfc\u4ed6\u4eec\u91cd\u65b0\u8bc4\u4ef7\u81ea\u5df1\u7231\u7684\u611f\u89c9\uff08\u6bd4\u5982\u201c\u7231\u4e0a\u4e00\u4e2a\u4e0d\u518d\u548c\u6211\u5728\u4e00\u8d77\u7684\u4eba\uff0c\u8fd9\u662f\u53ef\u4ee5\u7684\u201d\uff09\u3002\u7b2c\u4e09\u7ec4\u88ab\u8bd5\u5219\u4f1a\u88ab\u8be2\u95ee\u4e0e\u5206\u624b\u548c\u524d\u4efb\u65e0\u5173\u7684\u79ef\u6781\u4e8b\u7269\u7684\u95ee\u9898\uff08\u6bd4\u5982\u201c\u4f60\u6700\u559c\u6b22\u7684\u98df\u7269\u662f\u4ec0\u4e48\uff1f\u4e3a\u4ec0\u4e48\uff1f\u201d\uff09\u3002\u8fd9\u4e09\u7ec4\u90fd\u88ab\u8981\u6c42\u9759\u9ed8\u5730\u601d\u8003\u3001\u56de\u7b54\u548c\u9648\u8ff0\u3002<\/p>\n\n\n\n
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\u8f6c\u79fb\u6ce8\u610f\u529b\u867d\u7136\u4e0d\u662f\u4e00\u4e2a\u6709\u6548\u7684\u7231\u7684\u8c03\u8282\u7b56\u7565\uff0c\u56e0\u4e3a\u5b83\u6ca1\u6709\u6539\u53d8\u7231\u7684\u611f\u89c9\uff0c\u4f46\u5374\u662f\u6709\u6548\u7684\u60c5\u7eea\u4e0a\u8c03\u7b56\u7565\uff08up-regulation strategy\uff09\u3002\u53e6\u5916\uff0c\u8f6c\u79fb\u6ce8\u610f\u529b\u5e76\u4e0d\u5177\u6709\u957f\u671f\u6548\u679c\u3002<\/p>\n\n\n\n
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